Estrogen deficiency and bone loss: an inflammatory tale
نویسندگان
چکیده
منابع مشابه
Estrogen deficiency and bone loss: an inflammatory tale.
Estrogen plays a fundamental role in skeletal growth and bone homeostasis in both men and women. Although remarkable progress has been made in our understanding of how estrogen deficiency causes bone loss, the mechanisms involved have proven to be complex and multifaceted. Although estrogen is established to have direct effects on bone cells, recent animal studies have identified additional une...
متن کاملIncreased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.
While the prevalence of osteoporosis is growing rapidly with population aging, therapeutic options remain limited. Here, we identify potentially novel roles for CaV1.2 L-type voltage-gated Ca2+ channels in osteogenesis and exploit a transgenic gain-of-function mutant CaV1.2 to stem bone loss in ovariectomized female mice. We show that endogenous CaV1.2 is expressed in developing bone within pro...
متن کاملCardiovascular disease, estrogen deficiency, and inflammatory cytokines.
The incidence of hypertension increases in women after menopause, as does the susceptibility to myocardial infarction and other cardiovascular diseases.1 The mechanisms responsible for increased cardiovascular disease risk after menopause are unknown. However, postmenopausal women exhibit increases in inflammatory markers, such as C-reactive protein and inflammatory cytokines, which have been s...
متن کاملCepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption
1 Department of Orthopedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, 2 Orthopedic Research Institute of Zhejiang University, Hangzhou, China, 3 Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 4 Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kon...
متن کاملInflammatory Periprosthetic Bone Loss
Total hip arthroplasty [THA] is one of the most successful and effective procedures developed for the treatment of pain and lack of mobility associated with end-stage arthritis such as osteoarthritis and rheumatoid arthritis. Approximately 1.5 million joint arthroplastic operations are performed annually worldwide. THA, although considered an excellent surgical procedure, can be complicated by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2006
ISSN: 0021-9738
DOI: 10.1172/jci28550